A recent article in the Journal of Chromatography A with the very descriptive title “Comparison of preparative reversed phase liquid chromatography and countercurrent chromatography for the kilogram scale purification of crude spinetoram insecticide” makes a convincing case for the superiority of CCC over HPLC as a preparative technique. Spinetoram is the name given to a mixture of spinetoram-J and spinetoram-L which is prepared from the bacterial natural products called spinosyn J and spinosyn L. These closely-related compounds differ only by a double bond and a methyl group. The CCC instrument was 912.5 mL DE Midi HPCCC. The HPLC column was a 11x25 cm C8 column. Table 2 in the article provides a detailed comparison of the two methods and offers some insight into the chromatography parameters that may merit routine inclusion in CCC articles. Flow rate, sample loading, injection volume, recovery mass and purity are often recorded but parameters like sample throughput (kg/h), total mobile phase used, total fraction volume containing the products, and recovery % are less often reported. A couple of the big advantages of CCC are total fraction volume containing pure spinosyns (86 L vs 1196 L) and total mobile phase used (490 L vs 2560 L). A handful of examples may not have chromatographers standing in line to buy the latest CCC instrument, but they provide the world with a different perspective with which to favorably view liquid-liquid chromatography.